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We first provide a brief background on the multi-target cardiovascular effects of TCM-derived metabolites (Figure 1), then discuss evidence for their benefits in specific disease contexts (atherosclerosis, hypertension, myocardial infarction, heart failure), integrate findings from clinical studies, and finally consider the challenges and future directions for translating these therapies into mainstream cardiovascular care

ROS also induce calcium dysregulation, activating calpains and caspase-3 to accelerate cytoskeletal breakdown ( Mitochondrial dysfunction is central to chronic muscle loss, with supraspinatus fibers exhibiting reduced membrane potential, impaired ATP production, and increased ROS levels following RCTs (Yazdani et al., 2022)

Additionally, flavonoid-rich P